Abstract
The gut microbiota has tremendous potential to affect the host’s health, in part by synthesizing vitamins and generating nutrients from food that is otherwise indigestible by the host. 1,5-Anhydro-d-fructose (1,5-AF) is a monosaccharide with a wide range of bioactive potentials, including anti-oxidant, anti-inflammatory, and anti-microbial effects. Based on its potential benefits and minimal toxicity, it is anticipated that 1,5-AF will be used as a dietary supplement to support general health. However, the effects of 1,5-AF on the gut microbiota are yet to be clarified. Here, using an unbiased metagenomic approach, we profiled the bacterial taxa and functional genes in the caecal microbiota of mice fed a diet containing either 2% 1,5-AF or a reference sweetener. Supplementation with 1,5-AF altered the composition of the gut microbiota, enriching the proportion of Faecalibacterium prausnitzii. 1,5-AF also altered the metabolomic profile of the gut microbiota, enriching genes associated with nicotinamide adenine dinucleotide biosynthesis. These findings support the potential benefits of 1,5-AF, but further studies are required to clarify the impact of 1,5-AF on health and disease.
Highlights
The gut microbiota has tremendous potential to affect the host’s health, in part by synthesizing vitamins and generating nutrients from food that is otherwise indigestible by the host. 1,5-Anhydrod-fructose (1,5-AF) is a monosaccharide with a wide range of bioactive potentials, including antioxidant, anti-inflammatory, and anti-microbial effects
Principal coordinate analyses indicated that the structure of the gut microbiota in mice was distinguishable based on whether their chow was supplemented with 1,5-AF or not (Fig. 1A)
The proportion of Faecalibacterium prausnitzii was higher in mice fed with 1,5‐AF diet com‐ pare with those fed with control diet
Summary
The gut microbiota has tremendous potential to affect the host’s health, in part by synthesizing vitamins and generating nutrients from food that is otherwise indigestible by the host. 1,5-Anhydrod-fructose (1,5-AF) is a monosaccharide with a wide range of bioactive potentials, including antioxidant, anti-inflammatory, and anti-microbial effects. 1,5-AF altered the metabolomic profile of the gut microbiota, enriching genes associated with nicotinamide adenine dinucleotide biosynthesis These findings support the potential benefits of 1,5-AF, but further studies are required to clarify the impact of 1,5-AF on health and disease. The gut microbiota has tremendous potential to affect the host’s health It plays an important role in educating the host immune system, providing protection against pathogen overgrowth, synthesizing vitamins, and generating nutrients from food that is otherwise indigestible by the h ost[1,2]. Given the anti-microbial, anti-diabetic, and anti-oxidant properties of 1,5-AF, it can be assumed that dietary supplementation with 1,5-AF will modulate the gut microbiota, with an indirect impact on the host’s health. Using an unbiased metagenomic approach, we profile the bacterial taxa and functional genes in the caecal contents of mice that consumed chow supplemented with 1,5-AF or a reference sweetener
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