Abstract
TYPE: Abstract TOPIC: Chest Infections PURPOSE: COVID-19 is the leading cause of death in the United States for the last two years. Host susceptibility and pre-existing co-morbidities plays role in dictating COVID19 pathogenesis. Mitochondrial nucleotide-binding oligomerization domain-like Receptor X1(NLRX1) is an atypical NLR which plays a critical role in connecting innate immune responses with a variety of viral infections. Up to 30% of the general population carries rs10790286 single nucleotide polymorphism (SNP) of NLRX1 which can potentially alter susceptibility to COVID19. We aim to study an association of this SNP in NLRX1 with COVID19 infection. METHODS: We investigated 64 subjects with positive COVID19 PCR test admitted to the hospital with hypoxic respiratory failure. After written consent, blood was drawn, and genotyping assay was performed. Fischer exact test was used to assess the expression data with controls. RESULTS: No statistical difference was found for NLRX1 polymorphism and COVID19 susceptibility (p = 0.499). Similarly, no significant association between NLRX1 SNP and 30-day mortality was observed (p = 0.746). CONCLUSIONS: rs10790286 SNP of the NXLR1 gene is not associated with increased susceptibility and mortality for COVID19 related respiratory failure. CLINICAL IMPLICATIONS: Further research is needed to determine host susceptibility at molecular level for COVID19 related respiratory failure. DISCLOSURE: Funding: NIH R01 ES031253 (SH), NIGMS U54GM104942 (SH Pilot PI). KEYWORD: COVID-19
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