Potential Protection of Vitamin C and Bungur Leaf against Ulcerative Colitis

Abstract

Background/Aim: Ulcerative colitis is an inflammation of the large intestine with symptoms such as abdominal pain, bloody diarrhea, and rectal urgency. Ulcerative ix colitis is the most common form of inflammatory bowel disease worldwide (6–12 per 100,000 population with a prevalence of 76–150 per 100,000 population). The exact etiology of ulcerative colitis is unknown. However, it is suspected that genetics, environmental factors, and microbiota play a role in the pathogenesis of ulcerative colitis. This study to review effect of bungur leaves (Lagerstroemia speciosa) and vitamin C in improving the condition of ulcerative colitis. Method: The used method in this article is a narrative review by collecting data from existing research, using 24 journals. 14 Q1 indexed journals, 7 Q2 indexed journals, 4 Q3 indexed journals, and 1 textbook. Based on the results of the research collected, the effect of vitamin C and extracts of bay leaf as anti-inflammatory in ulcerative colitis will be shown. The research is based on PICO (Population, Intervention, Comparation, Outcome), using the Journal search tool obtained from the Pubmed, Google Scholar, and NCBI search tools, which are used as research material and processed into new information related to the purpose of writing. Results and Discussion: Based on the results of the literature review, vitamin C and Lagerstoemia s. leaves can play a role in overcoming oxidative stress in ulcerative colitis by reducing levels of proinflammatory cytokines. Conclusion: Vitamin C and bungur leaves play a role in improving the condition of ulcerative colitis. Keywords: Anti-inflammation, Ulcerative colitis, Vitamin C, Lagerstroemia speciosa, Bungur Leaves.