Abstract
The present study deals with evaluation of antioxidant, wound healing and anti-inflammatory activity of ethanolic extract of Curcuma longa Linn rhizomes. The ethanolic extract prepared by maceration technique was subjected to screen for antioxidant activity using DPPH radical scavenging method and wound healing activity using incision, excision, histopathological and dead space wound model and the study was supported with evaluation of granuloma tissue to estimate hydroxyproline content and histopathological evaluation. The anti-inflammatory study was carried out by using carageenan induced rat paw odema method. The tested extract of different dilutions in range 200µg/ml to 1000 µg/ml shows activity in range of 9.34% to 18.55%. Significant increase in wound closure rate, skin breaking strength, granuloma breaking strength was observed. The hydroxyproline content was also increased with decrease in scar area. The initial healing action might be due to increased collagen deposition and better alignment, with the obtained results it can be concluded that Curcuma longa extract has significant wound healing activity and initial healing may be due to presence of some terpenoids and antimicrobial agents. The extract shows prominent anti-inflammatory activity as compared to that of standard (Ibuprofen gel). The extract shows good anti-inflammatory activity on carageenan induced rat paw odema method.
Highlights
Curcuma longa Linn (Zingiberaceae) is distributed in India, Pakistan, China and other tropical countries
After the histopathological evaluation of slides the Curcuma longa treated wound shows prominent promotion of keretinization, epithelization, fibrosis and collagen formation, the results are compared with untreated group and wounds treated with Framycetine Sulphate Cream (FSC) cream was consider as reference standard
In excision wound healing study from the observed values it were assumed that Curcuma longa extract shows better and faster healing as compared to untreated group
Summary
Curcuma longa Linn (Zingiberaceae) is distributed in India, Pakistan, China and other tropical countries. The colouring matter present in the rhizomes of Curcuma longa is curcuminoides that include curcumin, demethoxy curcumin and bis demethoxy curcumin[1]. These compounds are diaryl heptanoid compounds of dark yellow colour. Wound healing is a process which is fundamentally a connective tissue response. Initial stage of this process involves an acute inflammatory phases followed by synthesis of collagen and other extracellular macromolecules which are latter remoulded to form scars[16,17]. The present study deals with the use of traditionally claimed use of Curcuma longa. Anti-inflammatory study was screened by carageenan induced paw odema method
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