Potential of calcium silicate as a coating material on maghemite(γ-Fe2O3) for hyperthermia treatment

Abstract

Through previous research, the excellent biocompatibility and bioactivity of calcium silicate were proven with the wide use in biomedical application. In this work, calcium silicate was synthesized from tetraethylorthosilicate (TEOS) and calcium nitrate tetrahydrate with calcium oxide: silicon dioxide (CaO: SiO2) ratio of 30:70 using sol-gel method. Chemical composition of CaO and SiO2 were analyzed using X-ray diffraction (XRD) and X-ray fluorescent (XRF). Magnetic Nanoparticles (MNPs) are gaining interest in all biomedical related application. However the usage of MNPs can’t be used directly and needed coating layer to improve the dispersion stability, biocompatibility and provide functionality. MNPs materials used in this research are maghemite (γ-Fe2O3). Maghemite was synthesized from ferrous chloride (FeCl3) and ferric chloride (FeCl2) with ratio FeCl3 to FeCl2 2:1 using sol gel method. Through this research, the potential of new coating materials which is calcium silicate to coat on maghemite while maintained the magnetic properties were studied and analyzed using VSM, XRD and XRF.Through previous research, the excellent biocompatibility and bioactivity of calcium silicate were proven with the wide use in biomedical application. In this work, calcium silicate was synthesized from tetraethylorthosilicate (TEOS) and calcium nitrate tetrahydrate with calcium oxide: silicon dioxide (CaO: SiO2) ratio of 30:70 using sol-gel method. Chemical composition of CaO and SiO2 were analyzed using X-ray diffraction (XRD) and X-ray fluorescent (XRF). Magnetic Nanoparticles (MNPs) are gaining interest in all biomedical related application. However the usage of MNPs can’t be used directly and needed coating layer to improve the dispersion stability, biocompatibility and provide functionality. MNPs materials used in this research are maghemite (γ-Fe2O3). Maghemite was synthesized from ferrous chloride (FeCl3) and ferric chloride (FeCl2) with ratio FeCl3 to FeCl2 2:1 using sol gel method. Through this research, the potential of new coating materials which is calcium silicate to coat on maghemite while ...