Abstract
Several studies have shown that oxidative damage to various organs of a given organism is involved in causing various diseases, and in this context, the brain is highly vulnerable to oxidative stress because of its high metabolic rate, low capacity of cell regeneration, small amounts of enzymatic and non-enzymatic antioxidants. Oxidative stress is caused by an imbalance in cell redox state, in which there is excessive production of reactive oxygen species and/or failure of antioxidant defense systems. Consequently, oxidative stress in brain has shown direct implications in the pathogenesis of several neuro-degenerative diseases such as Alzheimer's, Parkinson's, Huntington's, Schizophrenia and amyotrophic lateral sclerosis. In this review, the critical role of oxidative stress in neuro-degenerative diseases as well as some aspects of antioxidant compounds (phenolic compounds and vitamins) regarding prevention and/or treatment of Alzheimer's, Parkinson's, Huntington's, Schizophrenia and amyotrophic lateral sclerosis were evaluated. Key words: Natural antioxidants, brain, neurodegenerative diseases, oxidative stress.
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