Potential effect antidiabetic of a medicamentous receipt made up of Parquetina nigrescens (Periplocaceae) and Erythrina senegalensis (Fabaceae) and effects on the lipidic profile and the glycation of hemoglobin in rats diabetics

Abstract

The medicinal recipe composed of Parquetina nigrescens (Periplocaceae) and Erythrina senegalensis (Fabaceae) is a remedy used in traditional medicine in Côte d'Ivoire to treat diabetes. this study aims to assess the potential anti-diabetic effect of the drug recipe (RPNES) and its effect on the lipid profile and hemoglobin glycation in diabetic rats. Diabetes mellitus is induced by an intraperitoneal injection of streptozotocin, dissolved in a citrate buffer solution, at a dose of 65 mg/kg BW and a nicotinamide solution at a dose of 230 mg/kg BW to Wistar rats. Healthy rats and diabetic rats are treated orally with RPNES daily for 28 days and blood samples from control and treated rats are taken for assay of biochemical parameters. This study shows that RPNES, administered at doses greater than or equal to 600 mg/kg BW, causes a significant decrease in blood sugar in diabetic rats. in addition, a significant decrease in serum total cholesterol and triglyceride levels, associated with an increase in serum HDL cholesterol level, was observed in diabetic rats which received RPNES at 800 mg/kg BW, after 28 days treatment. In addition, after 90 days of treatment, RPNES (800 mg/kg BW) induces a significant decrease in the percentage of glycated hemoglobin in diabetic rats. This study also revealed that, in diabetic rats, RPNES had antihyperglycemic and antidiabetic effects similar to those of glibenclamide. RPNES is also a hypolipemic substance which corrects lipid disorders associated with diabetes, normalizes HDL cholesterol and lowers HbA1c levels in diabetic rats. These results justify the use in traditional medicine of this medicinal recipe composed of Parquetina nigrescens and Erythrina senegalensis to treat diabetes.