Abstract
Introduction: Drug-drug interactions are an important clinical problem in pharmacotherapy. This study is focused on different types of drugs used in a psychiatric hospital.
 Materials and methods: The pharmacoepidemiological study included the analysis of medical records of 500 psychiatric inpatients. The patients were divided into 2 groups: under 65 and over 65 years of age. All the drug prescriptions were analyzed to identify the combinations of drugs that can induce drug-drug interactions and determine their clinical significance.
 Results and discussion: Over 77% of hospitalized patients were administered drug combinations that could induce drug-drug interactions, most of which were of moderate clinical significance. A reliable association was found between the patient’s age, the clinical significance of drug-drug interactions, and the pharmacotherapy structure. The most common irrational drug combinations were identified.
 Conclusion: Timely analysis of drug prescriptions for potential drug-drug interactions can enhance the safety of pharmacotherapy and decrease the risk of adverse drug reactions in the psychiatric inpatient setting.
Highlights
Drug-drug interactions are an important clinical problem in pharmacotherapy
Comorbidities, drug resistance, and willingness to accelerate recovery are the causes of multiple drug prescription, which increases the risk of adverse drug reactions, which in this case are mainly due to drug-drug interactions
This analysis was aided by a drug-drug interaction identification tool, the Drug Interaction Checker found at http://www.drugs.com, which provides data that is in agreement with the official prescribing information for medicinal products approved by the United States Food and Drug Administration (FDA).The information obtained on potential drug-drug interactions was compared with the official instructions for medical use from the State Register of Medicines
Summary
Drug-drug interactions are an important clinical problem in pharmacotherapy. This study is focused on different types of drugs used in a psychiatric hospital. All the drug prescriptions were analyzed to identify the combinations of drugs that can induce drug-drug interactions and determine their clinical significance. Results and discussion: Over 77% of hospitalized patients were administered drug combinations that could induce drug-drug interactions, most of which were of moderate clinical significance. Conclusion: Timely analysis of drug prescriptions for potential drug-drug interactions can enhance the safety of pharmacotherapy and decrease the risk of adverse drug reactions in the psychiatric inpatient setting. The current rational drug therapy of psychiatric diseases is based on the two main principles of efficacy and safety. The former aspect is quite successfully controlled by clinical practitioners on the basis of changes in the clinical condition, whereas safety monitoring requires certain skills from the physician.
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