Abstract
The incidence of cancer is increasing each year, which generates concerns regarding the efficacy of the current treatment options. This has caused patients to seek alternatives to complement or to replace surgery, chemotherapy and radiotherapy. Annona muricata and other plants have been shown to have promising compounds that can be utilised in the treatment of cancer. Native to the tropical and subtropical parts of the world, A. muricata plant extracts contain compounds that are particularly effective against cancer cells. In light of increasing concerns regarding the limitations of cancer treatment in hospitals, this review attempts to highlight the benefits of A. muricata and its potential to be integrated as one of the treatment options against cancer.
Highlights
Cancer, including breast cancer, has become a major health concern worldwide
We explore some of the benefits of complementary and alternative medicines (CAMs), Annona muricata, as potential treatments agent against breast cancer and other forms of cancer
The analyses showed that A549 cells treated with A. muricata extracts experience inhibition in growth capability as well as upregulation of the apoptosis pathway
Summary
Cancer, including breast cancer, has become a major health concern worldwide. It is estimated by the World Health Organization (WHO) that in the period between 2005 and 2015, 84 million deaths would be attributed to cancer [2]. A study using A. muricata leaf extracts showed toxicity towards cancer cell lines MCF-7, MDA-MB-231 and 4 T1, but less toxicity towards the normal breast cell, MCF10A [60], which shows that these AGEs target cancer cells, not normal cells These observations suggest the potential use of AGEs as treatment options against cancer. A separate study by Rachman showed that the ethanol extracts of leaves of the soursop plant extracted into ethanol induce cytotoxic activity within the breast cancer cell line MCF7 [72]. Another study by Gavamukulya showed that a similar ethanol extract of the soursop plant leaves was found to be highly cytotoxic in vitro against the two human breast cancer cell lines MDA and SKBR3 [31]. 38.5 μg/ml polyketide derivatives isolated from the plant were shown to have a synergistic effect with every concentration of doxorubicin used during the treatment of Hela cells [80]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
