Potent anti-oxidant and anti-inflammatory potentials of Punica granatum leaf and flower hydromethanolic extracts in vitro

Ibtsam Gheith,Abubakr El-Mahmoudy

doi:10.14393/bj-v33n2-33736

Abstract

Potent anti-oxidant and anti-inflammatory potentials of Punica granatum leaf and flower hydromethanolic extracts in vitro

Highlights

Biological processes necessary for life are associated with continuous production and release of free radicals, which are physiologically scavenged by antioxidant defence mechanisms
A third product coming from both oxygen and nitrogen radicals that is peroxynitrite (ONOO-), which occurs at a limited rate (HALLIWELL, 2011)
Epidemiological studies support the relationship between oxidative state and global health; where high consumption of foods rich in antioxidants is associated with lower disease rates and preventive protection (WANNAMETHEE et al, 2006)

Summary

Introduction

Biological processes necessary for life are associated with continuous production and release of free radicals, which are physiologically scavenged by antioxidant defence mechanisms. Under normal conditions, both oxidant and antioxidant arms are in balance with benefit and no harm to the living body cells and organs. Reactive oxygen species (ROS) includes oxygen chemicals that take part in radical type reactions (i.e. gain or loss of electrons). These chemicals are either of non-radical ROS (do not have unpaired electrons) type as hydrogen peroxide (H2O2), hypochlorous acid (HOCl) and ozone (O3); or of true radical ROS type as superoxide anion radicals (O2-) and hydroxyl radical species (-OH). ROS may be generated in harmony through mitochondrial respiration, arachidonic acid metabolism, the activation of polymorphonuclear leukocytes, enzymatic functions, and iron or copper mediated catalysis (GUPTA; VERMA, 2010)

Methods

Discussion

Conclusion