Abstract
This chapter discusses the potassium penicillin V. The chapter contains updated information pertaining to the analytical chemistry of potassium phenoxymethylpenicillin. The original profile2 contains the infrared spectrum of potassium phenoxymethylpenicillin prepared as a potassium bromide pellet. Kuzhelyuk 3 showed through the interpretation of infrared spectra that phenoxymethylpenicillin exists in the acid form, 6-aminopenicillanic acid as a zwitterion and potassium benzylpenicillin (potassium penicillin G) as an ionic structure. The infrared spectra of aqueous antibiotic solutions including potassium penicillin V were obtained by using a Liquid Analyzer accessory in a Fourier-transform IR spectrometers. Structural information based on the infrared spectra of penicillin V and its sodium salt allowed Siemon et al. 6 to assign a trans conformation to the amide bond of the free acid and a cis conformation to the amide bond of the sodium salt.
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