Potassium 6-Oxo-7,13,16,22-tetraazatetracyclo[12.6.2.18,12.017,21]tricosa-1(20),8(23),9,11,14,16,18,21-octaen-2-yne-15-carboxylate

Camille Blouet,Caroline Denevault-Sabourin,Thomas Robert,Noël Pinaud,Nicolas Joubert,Cédric Logé,Stéphanie Letast,Stéphane Bach,Jean Guillon,Marie-Claude Viaud-Massuard

doi:10.3390/m1735

Potassium 6-Oxo-7,13,16,22-tetraazatetracyclo[12.6.2.18,12.017,21]tricosa-1(20),8(23),9,11,14,16,18,21-octaen-2-yne-15-carboxylate

Camille Blouet, Caroline Denevault-Sabourin + Show 8 more

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https://doi.org/10.3390/m1735

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Journal: Molbank	Publication Date: Oct 9, 2023
License type: CC BY 4.0

Affiliation: Université de Tours, Laboratory of Integrative Biology of Marine Model, Sorbonne Université, French National Centre for Scientific Research, Roscoff Marine Station, University of Bordeaux, Institute of Molecular Sciences, Nantes Université, North-West University, Inserm

#Interesting Selectivity Profile #Multi-step Pathway + Show 8 more

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Abstract

Potassium 6-oxo-7,13,16,22-tetraazatetracyclo[12.6.2.18,12.017,21]tricosa-1(20),8(23),9,11,14,16,18,21-octaen-2-yne-15-carboxylate was synthesized through a multi-step pathway, starting from commercially available 3-iodo-1,2-phenylenediamine. Structure characterization of this new substituted macrocyclic quinoxaline compound was achieved using 1H NMR, 13C NMR, and HRMS spectral analysis. This new macrocyclic derivative demonstrated submicromolar potency on both Pim-1 and Pim-2 isoforms, with an interesting selectivity profile against a selected panel of human kinases.

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