Abstract
Motor responses were studied in neonatal rats of the GC strain, which is characterized by hereditary catatonia. These pups differed from control Wistar pups in having a greater proportion of dyskinetic movements and postures on days 1–2 of neonatal development and a lower number of motor actions in later development. GC pups had elevated noradrenaline levels in the hemispheres on the 7th, 10th, and 14th days in comparison to Wistar rats and in the brainstem on day 10. In GC pups, the amount of serotonin in the hemispheres on days 1 and 14 and in the brainstem on day 14 was lower than in Wistar rats. The level of 5-hydroxyindoleacetic acid in GC pups was lower than in Wistar on days 1 and 7. We compared the characteristics of transmitter mechanisms on the basis of various models: GC rats, pharmacological in vivo models, and spinal in vitro preparations from animals at early developmental stages.
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