Abstract
Chronic administration of imipramine (7.5 mg/kg) led to stable reactions consisting of decreases in excitability in response to sound stimuli in Wistar rats and a phasic behavioral response in rats of the catatonic strain GC. Wistar rats showed increases in frontal cortex and striatum noradrenaline levels in Wistar rats, while there were no differences in noradrenaline levels in any of the brain structures studied in GC rats. Increases in plasma corticosterone levels in GC rats decreased in response to the antidepressant. In intact GC rats, triglyceride levels and body weight were lower and relative adrenal weight was higher than in Wistar rats. It is suggested that there are different pathways mediating the effects of imipramine: in Wistar rats via influences on the noradrenergic system of the brain, which is involved in regulating psychoemotional states, and in GC rats via influences on the functional state of the adrenal cortex.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
