Abstract
Chronic administration of imipramine (7.5 mg/kg) led to stable reactions consisting of decreases in excitability in response to sound stimuli in Wistar rats and a phasic behavioral response in rats of the catatonic strain GC. Wistar rats showed increases in frontal cortex and striatum noradrenaline levels in Wistar rats, while there were no differences in noradrenaline levels in any of the brain structures studied in GC rats. Increases in plasma corticosterone levels in GC rats decreased in response to the antidepressant. In intact GC rats, triglyceride levels and body weight were lower and relative adrenal weight was higher than in Wistar rats. It is suggested that there are different pathways mediating the effects of imipramine: in Wistar rats via influences on the noradrenergic system of the brain, which is involved in regulating psychoemotional states, and in GC rats via influences on the functional state of the adrenal cortex.
Published Version
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