Abstract
ABSTRACT Ten normally menstruating women, ranging in age from 19—32, received 5 mg of megestrol acetate plus 0.1 mg of mestranol from day 20 of the cycle daily for 20 days. Individual 48 h urine collections were obtained from cycle days 7—8, 13—14, 18—19, and from days 9—10 and 19—20 during the treatment. Each 48 h specimen was assayed for »total« gonadotrophins, 17-KGS and fractionated 17-KS. The basal temperature and occurrence of menstruation were noted before, during and after the treatment. In 7 cases unequivocal suppression of gonadotrophins was observed during the medication period, and all these women had their expected menstruation postponed until after termination of the treatment. The next menstrual cycles were ovulatory and regular in relation to the postponed menstruation. In 3 cases no suppression of gonadotrophins was observed and these same cases had no postponement of menstruation. The mean excretion of 17-ketogenic steroids and of 17-ketosteroids (total 17-KS, dehydroepiandrosterone, androsterone and aetiocholanolone fractions) in the whole group was significantly depressed at the end of the treatment period.
Published Version
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