Abstract
Visual callosal projections were studied in normal adult rabbits, and in adult rabbits in which normal development was manipulated by monocular enucleation on the first or seventh postnatal day, or by abolition of retinal physiological activity by repeated application of tetrodotoxin (TTX) beginning on postnatal day 7. Animals given control vehicle injections, and animals enucleated on postnatal day 7 did not differ from normal in the tangential extent of their callosal zone which is limited to the lateral one-third of area 17. In contrast, animals enucleated on the day of birth and animals given TTX vitreous injections beginning on postnatal day 6–7 are similar in that the tangential extent of their callosal cell zone extends approximately through the lateral two-thirds of area 17. The results suggest that different mechanisms underly the effects of removal of the eye, and abolition of retinal activity, and that the critical period for the effective manipulation of these two mechanisms is different.
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