Abstract
Muscarinic depression of field potential excitatory postsynaptic potentials (fEPSPs) in stratium radiatum of area CA1 was compared in hippocampal slices from rats of different ages. Bath application of 4 μM muscarine reversibly depressed the fEPSP slope by 68.4% in slices from adult animals (P43–P60), but caused only a 32.2% depression in slices from P5–P7 animals. The magnitude of the depression increased with age during the first postnatal month. Reduced sensitivity of excitatory synaptic transmission to cholinergic depression during postnatal development could be one factor contributing to the hyperexcitability of immature hippocampus.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
