Abstract
Introduction: Treatment of major depression (MDD) often requires multiple trials of medications before an effective therapy can be identified, this poses a serious issue as it is associated with an increased risk of suicide and can contribute to worsening co-morbidities. In late-life depression (LLD), as the time required to respond to a single medication is on average longer (6 weeks compared to 4) – these risks may be worsened. Several studies have shown changes in functional activation/connectivity following acute doses as measured by functional magnetic resonance imaging (fMRI). In this study, we aimed to investigate early changes in functional brain activation (during emotion reactivity) that occur during a treatment trial.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
