Abstract
Background Recently, immunogenetic studies have demonstrated a potential association between atopy and metabolic syndrome in children. Several susceptibility genes have been linked between obesity, diabetes and atopy, such as CTLA4 (CD28-ICOS), IL12b, ADRB2, TNFa and LTA4. It has also been noted that obese atopic patients have different clinical manifestation compared to those not obese, for instance, systemic inflammation is often more severe and bronchial hyperreactivity tends to be more acute. On the other hand, pulmonary function, quality of life in terms exercise tolerance and involvement in recreational activities is poorer.
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