Abstract
The immediate post-training administration of Leu-enkephalin or of β-endorphin (10 μg/kg, ip) in rats causes retrograde amnesia, both for the habituation of a rearing response to a tone, and for shuttle avoidance behavior. The facts that the doses employed were very low, and that in previous papers the opiate antagonist, naloxone, was found to have an opposite effect, suggest that endogenous opiates are physiologically active amnesic agents.
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