Commentary: Rehebbilitating Memory.

Pascale Gisquet-Verrier,David C Riccio

doi:10.3389/fnbeh.2016.00078

Abstract

Commentary: Rehebbilitating Memory.

Highlights

In 2015, two papers using very different procedures presented strong evidence indicating that amnesia induced by protein synthesis inhibitor did not prevent memory formation, challenging the classical consolidation hypothesis (Gisquet-Verrier et al, 2015; Ryan et al, 2015)
These studies were not consistent with a consolidation hypothesis postulating that interrupting the stabilization processes should lead to a permanent loss of the memory, and rather suggested that amnesia resulted from retrieval difficulties (Lewis, 1979)
In the case of post-reactivation amnesia, the morphological changes thought to be induced by initial training normally took place after training, as rats demonstrated substantial levels of freezing during memory reactivation, indicating that retrieval processes were in place at that time

Summary

Introduction

In 2015, two papers using very different procedures presented strong evidence indicating that amnesia induced by protein synthesis inhibitor did not prevent memory formation, challenging the classical consolidation hypothesis (Gisquet-Verrier et al, 2015; Ryan et al, 2015). In their recent review, Ryan and Tonegawa (2016) went further and proposed that retrieval difficulties were due to the absence of training-induced morphological changes induced by protein synthesis inhibition. These studies were not consistent with a consolidation hypothesis postulating that interrupting the stabilization processes should lead to a permanent loss of the memory, and rather suggested that amnesia resulted from retrieval difficulties (Lewis, 1979).

Results

Conclusion