Post-synthetic modification of MIL-53(Fe) with Tb3+ and guanosine monophosphate: Construction of a fluorescent dual-target sensor

Abstract

The development of fluorescence-based multi-target sensing sensors has great potential for applications in food safety monitoring and biomedical analysis. Nevertheless, the intricate design remains a hurdle in the construction of these sensors. Luminescent metal-organic frameworks (LMOFs) are suitable materials for the construction of multi-target fluorescent sensors due to their ability to introduce multiple luminescent centers and specific reaction sites through post-synthetic modification (PSM). In this study, a dual-target fluorescent sensor was fabricated via PSM of MIL-53(Fe) with Tb3+ and guanosine monophosphate (GMP). The Tb-GMP@MIL-53(Fe) sensor, with multiple luminescent centers and specific recognition sites, successfully achieved the detection of hydrogen peroxide (H2O2) and acid phosphatase (ACP) with a limit of detection (LOD) of 0.18 μM and 0.73 U/L, respectively. More significantly, this study demonstrates the potential of post-synthetic modified LMOFs in developing dual/multiple-target fluorescent sensors, expanding the scope of sensor designs for various analytes.