Abstract
Background and Aims : Background: Thrombocytopenia has been reported in patients with the familial chylomicronemia syndrome (FCS) due to complete lipoprotein lipase deficiency (LPLD), treated or not with volanesorsen, a second generation APOC3 anti-sense oligonucleotide. Chylomicrons are the lipoproteins delivering fat after a meal and therefore, FCS is a post-prandial disease. Platelet count and activity have not been studied post-prandially in FCS. Objective: To evaluate post-prandial fluctuations in the platelet count and platelet activity in relation to other hematologic parameters in FCS vs controls.
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