Abstract
Decrease in the in vitro uptake of 14C-AA's by the dogfish lens cortex and in their incorporation into its proteins occurred as a result of lens incubation in a near UV light chamber. Alterations in capsular and fiber cell membrane permeability resulting from near UV irradiation seemed to be the cause of this change. A decreased rate of formation of all soluble lens proteins in maturing mouse lenses also occurred between 16 and 43 weeks of near UV exposure. In addition, the rate of accumulation of lens insoluble proteins was stimulated by near UV exposure for the same length of time. Quantitative changes in the distribution of ten specific soluble proteins were noted. Qualitative changes in sulfonated insoluble lens proteins were also found. The results support the idea that age-related cataractous changes in the lens are accelerated by near UV light.
Published Version
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