Abstract
H2S has been proposed as physiological important molecule. It is considered as first endogenous gaseous K+ channel opener. K+ ATP channel activity is mainly responsible for insulin secretion. K+ATP channel opening of β cells leads to inhibition of insulin secretion and channels closing leads to secretion. H2S is the gaseous K+ ATP channel opener but it does not have channel specificity. So, H2S may have some effect on insulin secretion. H2S is high in Zuker diabetic fatty rats. That means H2S is high in insulin resistance condition. We tried to find out the role of H2S in insulin secretion and in development of insulin resistance. From the result of our study, H2S have K+ ATP channel opening activity on β cells. H2S does not have any role in the development of insulin resistance. Decrease in insulin level in Zuker diabetic rat and streptozotocin-induced diabetic rat is due to high H2S level.
Highlights
IntroductionInterest has been directed toward other naturally occurring gases, notably H2S
In recent years, interest has been directed toward other naturally occurring gases, notably H2S
Administration of H2S results in an increase in glucose level and a decrease in insulin level which became normal after 5 h [Table 1]
Summary
Interest has been directed toward other naturally occurring gases, notably H2S. H2S has been proposed as physiological important molecule. High concentration of H2S has been observed in brain of rats, humans, and cows. The H2S concentration in rat serum has been found to be 46 μM[1] and in brain tissue 50-160 μM.[2] Significant amount of H2S is produced in various tissues. Cystathionine gamma lyase (CSE), cystathionine β synthase (CBS), and 3-mercaptosulfurtransferase are the enzymes responsible for production of H2S.[3] The main subtract for these enzymes is L-cysteine. H2S is considered as endogenous vasorelaxant factor and cardiovascular function regulator.[4] Zhao showed that H2S is the first gaseous K+ATP channel opener.[1] Intravenous injection of
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