Abstract
COVID-19 infection is more severe in patients with type 2 diabetes mellitus (DM2). The severity of this viral infection is associated with an intense inflammatory activity. DM2 is a disease that also determines a greater degree of systemic inflammation. This is due to hyperglycemia, the higher prevalence of sleep disorders and also the low levels of melatonin, a substance with anti-inflammatory actions, in these patients. In this article, we suggest that exogenous melatonin may have an important anti-inflammatory role in preventing severe forms of COVID -19 in patients with DM2.
Highlights
The COVID-19 pandemic manifests itself with adverse outcomes for some groups
As sleep disorders are frequent in DM2 is reasonable to think that this fact may contribute to severe forms of COVID-19 that are related to a higher inflammatory status
We conclude that melatonin modulates protective mechanisms against COVID-19
Summary
COVID-19 infection is more severe in patients with type 2 diabetes mellitus (DM2). The severity of this viral infection is associated with an intense inflammatory activity. DM2 is a disease that determines a greater degree of systemic inflammation. This is due to hyperglycemia, the higher prevalence of sleep disorders and the low levels of melatonin, a substance with anti-inflammatory actions, in these patients. We suggest that exogenous melatonin may have an important anti-inflammatory role in preventing severe forms of COVID -19 in patients with DM2.
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