Abstract
Abstract Cell cytoskeleton plasticity is now recognized as an important element of cell to cell and cell to antigen interactions. It has been shown that T cells and dendritic cells use shape changes in order to establish effective contacts between them. B lymphocytes also show cytoskeleton rearrangements during antigen recognition. The B cell surface change upon activation with LPS or anti-CD40 plus IL-4; these stimuli induce the generation of long thin microvilli, longer than those observed in resting conditions. These structures are formed by a central actin filaments bundle with bridging associated proteins that links them to plasma membrane. One of these proteins are class I myosins, which are molecular motors that interacts both with actin fibers and plasma membrane phosphoinositides; Myo1c and Myo1g are importantly expressed in B cells and appears to increase upon activation. By using live-cell microscopy we determined that they are present across microvilli structures and seems to be involved in their formation. Finally, our data suggest a role for microvilli by segregating molecules such as MHC-II, LFA-1, CD40, etc. possibly mediated by class I myosins. Supported by CONACyT, project 56836
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