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Abstract
MNNG induces gastric cancer in rats within 1 year after the administration as drinking water. Some investigators have suggested that the methylation of nucleic acids or protein by MNNG may be responsible for mechanism. carcinogenesis, but this does not completely explain the carcinogenic. We have examined the mechanism of l-metyl-3-nitro-lnitrosoguanidine( MNNG)-induced gastric cancer with respect to the production of hydroxyl free radical (·OH). This chapter shows that ·OH was produced with 1-methyl-3-nitroguanidine (MNNG) by the nucleophilic attack of H2O2 derived from the XO system on the nitroso group of MNNG via the formation of the intermediate peroxynitric acid (ONOOH) which splits into hydroxyl free radical (·OH) and nitrogen dioxide using ESR spin trapping technique, suggesting that the administration of MNNG to the gastric legion with the high XO activity results in the ·OH production.
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