Abstract
BackgroundThe coronavirus infection 2019 (COVID-19) is associated with microvascular endothelial injury. Here, we report that syndecan-1, a component of endothelial glycocalyx, may reflect the disease state of COVID-19 related to endothelial injury.Case presentationA patient with COVID-19 was transferred to the intensive care unit of our hospital. Computed tomography of the chest showed bilateral ground glass opacities, which was diagnosed as acute respiratory syndrome. The PaO2/FIO2 ratio gradually increased from 158 on hospitalization to 300 on Day 11, on which day the ventilator was withdrawn. However, serum syndecan-1 (SDC-1) level gradually decreased from 400.5 ng/ml at hospitalization to 165.1 ng/ml on Day 5. On Day 6, serum SDC-1 level increased to 612.9 ng/ml owing to a systemic thrombosis with an increase in D-dimer. Serum SDC-1 level then decreased until 206.0 ng/ml on Day 11 after a decrease in D-dimer. The patient was transferred to another hospital on Day 21 after hospitalization.ConclusionsIn this case report, changes in serum SDC-1 level closely reflected the change in disease condition in a patient with COVID-19. Serum SDC-1 may be a useful biomarker for monitoring the disease state of critically ill patients with COVID-19.
Highlights
The coronavirus infection 2019 (COVID-19) is associated with microvascular endothelial injury
In this case report, changes in serum SDC-1 level closely reflected the change in disease condition in a patient with COVID-19
Serum SDC-1 may be a useful biomarker for monitoring the disease state of critically ill patients with COVID-19
Summary
The coronavirus infection 2019 (COVID-19) is associated with microvascular endothelial injury. Conclusions: In this case report, changes in serum SDC-1 level closely reflected the change in disease condition in a patient with COVID-19. Recent reports have suggested that one of the mechanisms of ARDS induced by COVID-19 may be involved in microvascular endothelial cell injury [2]. We present the case of a COVID-19 patient with ARDS in whom serum SDC-1, a component of glycocalyx, was measured over time, and examine the
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