Abstract
The effect of total lipidic and saponifiable extracts from Sabal serrulata fruits on contraction induced by vanadate (0–3 mM) in the uterus of Wistar rats incubated in calcium-free solution have been assayed. The two extracts relaxed the contraction induced by vanadate. The EC50 values were 43.9 ± 8.4 and 11.4 ± 1.4 μg mL−1 for total lipid and saponifiable material, respectively. Total lipid and saponifiable extracts also inhibited calmodulin-dependent cAMP phosphodiesterase activity in a dose-dependent way. The EC50 values were 25.1 ± 4 and 28.6 ± 4 μg mL−1 for total lipid and saponifiable material, respectively. Phosphodiesterase basal activity was only modified with the maximum concentration (100 μg mL−1). These results suggest that the effects of extracts from Sabal serrulata fruits could be due, at least partially, to the inhibition of calmodulin but other mechanisms cannot be excluded.
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