Abstract
This chapter discusses the coexistence of cholecystokinin (CCK)-like immunoreactivity and dopamine that has been quantitatively evaluated by the means of new methodologies. Subsequently, the effects of cholecystokinin-8 have been characterized both on presynaptic and postsynaptic dopaminergic mechanisms in the striatum. The effects of CCK-8 on dopamine content and turnover were evaluated by injecting CCK-8 intraventricularly into unanaesthetized rats with or without simultaneous treatment with the tyrosine-hydroxylase inhibitor, α-methyltyrosine methyl ester. The in vitro effects of CCK-8 on postsynaptic striatal dopamine receptors were evaluated by using the radioligands 3 H-spiroperidol and 3 H-N-propylnorapomorphine. A basic step in the understanding of the functional meaning of coexistence is the possibility to assess coexistence in quantitative terms. Several approaches have been developed to evaluate coexistence in a quantitative way.
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