Possible Association Between Vaspin Serum Levels and C-Reactive Protein in Obese Women with Polycystic Ovarian Syndrome

Abstract

Objective To investigate the levels of vaspin and C-reactive protein in women with polycystic ovarian syndrome (PCOS) and to assess their potential as diagnostic markers for the condition. Methods Ninety adult women were involved in the study, fifty of whom were obese women diagnosed with PCOS, while forty women served as healthy controls in an observational, case-control study. Blood samples were obtained from the participants, and all of them were questioned by the researcher. Vaspin and C-reactive protein serum levels were measured using enzyme-linked immunosorbent assay specialized kits. Results The study found a significant increase in vaspin and C-reactive protein serum levels in women in the PCOS group compared with controls, with P-values of <0.000 and 0.006, respectively. Vaspin serum level showed an AUC of 0.835, indicating it is a very good diagnostic marker for PCOS, while C-reactive protein had an AUC of 0.635, making it a moderate diagnostic marker for PCOS. The study also found a significant correlation between vaspin (pg/ml) and C-reactive protein (mg/l) with a P-value of 0.006. Conclusion The study found a significant increase in vaspin (pg/ml) and C-reactive protein (mg/l) serum levels in females with PCOS compared to control groups, with a significant positive correlation between the two biomarkers in PCOS. This suggests that vaspin and C-reactive protein may serve as useful diagnostic markers for PCOS.