Possibilities of speciﬁc immunological tests in patients with TB/HIV coinfection

L N Motanova,M S Grabovskaya,I V Folts

doi:10.21292/2075-1230-2021-99-10-46-51

Abstract

The objective of the study: to study the possibilities of skin tests with tuberculosis recombinant allergen (TRA) in the diagnosis of tuberculosis in HIV-positive patients in the region with a high prevalence of tuberculosis.Subjects and Methods. Medical ﬁles of 85 patients were retrospectively analyzed, all the patients suﬀered from TB/HIV coinfection and underwent the skin test with TRA.Results. The skin test with TRA was found to be signiﬁcantly valuable for the diagnosis of tuberculosis in patients with TB/HIV coinfection. The correlation between the intensity of response to the TRA test and CD4+ count was detected (p = 0.011). The lowest values were observed for CD4+ counts below 100 cells/μL. The direct correlation between the intensity of response to TRA and the stage of HIV infection was proved. No eﬀect of the form of tuberculosis, the phase of the tuberculosis disease, or drug sensitivity on the intensity of response to TRA was found. Among tuberculosis patients with bacterial excretion (n = 48), 68.8% of patients responded positively to the TRA test, and in those with no bacterial excretion, the positive reaction was observed in 81.1%.

Highlights

Проведен ретроспективный анализ медицинских карт пациентов с туберкулезом и ВИЧ-инфекцией поликлинического отделения ГБУЗ «Приморский краевой противотуберкулезный диспансер»
Fig. The regression function characterizing the dependence of the presence and intensity of the response to the TRA test on CD4+ count
Туберкулез у больных с ВИЧ-инфекцией как национальная проблема // Туб. и болезни легких. ‒ 2013. ‒ No 10. ‒ 12 с

Summary

Results

The skin test with TRA was found to be significantly valuable for the diagnosis of tuberculosis in patients with TB/HIV coinfection. The correlation between the intensity of response to the TRA test and CD4+ count was detected (p = 0.011). The direct correlation between the intensity of response to TRA and the stage of HIV infection was proved. No effect of the form of tuberculosis, the phase of the tuberculosis disease, or drug sensitivity on the intensity of response to TRA was found. Among tuberculosis patients with bacterial excretion (n = 48), 68.8% of patients responded positively to the TRA test, and in those with no bacterial excretion, the positive reaction was observed in 81.1%. For citations: Motanova L.N., Grabovskaya M.S., Folts I.V. Possibilities of specific immunological tests in patients with TB/HIV coinfection.

Материалы и методы

Результаты исследования

Число пациентов абс

Характеристика корреляционной связи

МБТ отсутствие наличие

Лекарственная устойчивость МБТ