Abstract
Changes in pituitary and plasma LH concentrations after ovariectomy alone or in combination with single injections of various dosages of estrogen were evaluated. Investigations were conducted in immature and adult normal and sterile female rats to study changes with age and differences in thresholds of response to estrogen on LH synthesis vs. release. In immature rats (30 days of age) plasma LH was not detectable. Ovariectomy at 20 days of age, with autopsy 10 days later, resulted in an increase in plasma LH to 11.3 μg/100 ml although pituitary LH concentrations remained unaltered. Injection of 0.05 μg estradiol benzoate (EB)/100 g body wt 7 days after ovariectomy (day 27 of age) failed to alter significantly pituitary and plasma LH concentrations. With the injection of 0.1 fig EB/100 g body wt, a significant increase in pituitary LH occurred, while plasma LH concentrations were unaffected. Estrogen injected as 0.5 μg/100 g body wt inhibited LH release although pituitary LH synthesis was not suppressed an...
Published Version
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