POSA384 Identification of Complications Associated with COVID-19 Infection from Claims Data

Abstract

Growing evidences suggest that COVID-19 infection should be considered as a systemic disease which involves multiple organ systems leading to numerous respiratory and non-respiratory complications. The current study evaluated all the potential complications associated with COVID-19 infections from administrative claims data. This retrospective, cross-over and observational study included patients diagnosed with COVID-19 infection between 1st April to 30th September 2020 with ICD-10 CM diagnosis recorded in the a large deidentified database of US health insurance claims. Only the patients having continuous eligibility between 4 months before (baseline period) to 1-month post (follow-up period) the first diagnosis of COVID-19 (index date) were included in study. Frequency of all ICD-10-CM diagnosis codes occurring during baseline period and during follow-up period were evaluated. For every ICD-10 CM diagnosis code, the risk estimates and odds ratios (ORs) of association with COVID-19 were evaluated. The study included 208,886 patients with a mean (SD) age of 53.65 (21.4) years, 44% males and 56% females. 486 out of 1,564 ICD codes evaluated found to be statistically significant with COVID-19 infection exposure. Notable disorders having higher odds and high absolute risk included viral pneumonia (OR: 90.09; CI:73.12-111.00; absolute risk: 16.12%), acute respiratory distress syndrome (OR: 46.92; CI:28.42-77.48; absolute risk: 1.5%), respiratory failure (OR: 17.44; CI:16.18-18.81; absolute risk: 10.74%), sepsis (OR: 7.94; CI:7.21-8.75; absolute risk: 5.25%), acute kidney failure (OR: 5.70; CI:5.33-6.09; absolute risk: 6.30%), essential hypertension (OR: 1.78; CI:1.74-1.82; absolute risk: 16.77%), Ischemic heart disease (OR: 1.97; CI:1.88-2.05; absolute risk: 4.46%) and heart failure (OR: 2.39; CI:2.27-2.51; absolute risk: 3.58%). Apart from respiratory system which is the primary site of infection for COVID-19, many other organs like cardiovascular, kidney and liver with varying degree are also involved in COVID-19 infection.