Abstract
Diagnosis of acute kidney injury (AKI) in low-income settings is challenging as creatinine testing is not routinely available and serum creatinine is affected by age, nutritional status and glomerular hyperfiltration, a feature of sickle cell anemia (SCA). Alternative point-of-care biomarkers are needed to facilitate early detection of AKI in at-risk populations. We evaluated the diagnostic accuracy of a semi-quantitative point-of-care test of urine neutrophil gelatinase-associated lipocalin (uNGAL) to diagnose AKI in SCA at hospital admission.
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