Abstract
It has recently been suggested that the role of complement activation, mainly of the alternate pathway, in the pathogenesis of ANCA vasculitis is significant. Although ANCA-related necrotizing and crescentic glomerulonephritis is often referred to as a “pauciimmune” process, in certain cases there is deposition of immune complexes and complement in the glomeruli detected by immunofluorescence. Complement deposits in the kidney of patients with ANCA vasculitis correlate with greater kidney damage, more significant proteinuria, and general disease activity.
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