Abstract
Membranoproliferative glomerulonephritis, one of the main causes of nephrotic syndrome, is associated with a state of hypercoagulability that leads to increased risk of thrombotic events. Portosystemic collaterals may reopen due to reversal of the flow within the existing veins and be a presenting feature of thrombosis. We describe a patient who presented with large portosystemic collaterals and signs of portal hypertension and was subsequently found to be affected by membranous proliferative glomerulonephritis. Proteinuria and microscopic haematuria in a patient with signs of portal hypertension and no pre-existing liver disease should raise the suspicion of an underlying kidney disease.
Highlights
Membranoproliferative glomerulonephritis is one of the main causes of nephrotic syndrome in adults and can cause renal failure [1]
Renal vein and deep vein thrombosis may be associated with the nephrotic syndrome [2,3,4,5], and the risk appears to depend on the duration and severity of the syndrome and to correlate with very low albumin levels
The few reported cases of portal vein thrombosis in nephrotic patients have all occurred in males [6,7,8]
Summary
Membranoproliferative glomerulonephritis is one of the main causes of nephrotic syndrome in adults and can cause renal failure [1]. Renal vein and deep vein thrombosis may be associated with the nephrotic syndrome [2,3,4,5], and the risk appears to depend on the duration and severity of the syndrome and to correlate with very low albumin levels. Portal vein thrombosis has been rarely reported [6,7,8]
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