Porphyrin-based magnetic porous organic polymer for efficient magnetic solid phase extraction of nonsteroidal anti-inflammatory drugs from water

Abstract

The ubiquitous occurrence of nonsteroidal anti-inflammatory drugs (NSAIDs) in the environmental water system has drawn significant concerns due to their adverse effects. The accurate monitoring the content of them is of great significance but challenging in terms of the complex matrix and trace concentration. In this work, a porphyrin-based magnetic porous organic polymer composite (PM-POP) was prepared through a solvent-free synthetic method. Owing to the highly porous structure and strong affinities, the as-prepared PM-POP could be utilized as a highly efficient adsorbent for the magnetic solid phase extraction (MSPE) of NSAIDs. Combining with the high-performance liquid chromatography separation with ultraviolet detector (HPLC-UV), a sensitive analytical method was established, which exhibited wide linear ranges (0.1–400 μg/L) and large enrichment factors (EFs) (39.5–82.9 folds) along with good precision (intra-day RSD ≤ 4.9%) and repeatability (inter-day RSD ≤ 8.4%). Ultimately, it was applied to determinate trace NSAIDs in practical water samples successfully, demonstrating its good application prospect in environmental analysis.