Porphyrin biosynthesis I. Studies on erythrocyte preparations

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Further studies have been reported on the identification of the biosynthetic porphyrins which are formed on incubation of supernatant preparations obtained from chicken red-cell haemolysates and δ-aminolaevulic acid or porphobilinogen under both anaerobic and aerobic conditions. Pseudo-uroporphyrin was identified as the so-called “208” porphyrin isolated from porphyria material. It is suggested that this porphyrin should be called phyria-porphyrin III, as was proposed in 1955. Chromatography on columns of CaCO 3 has proved to be a very sensitive tool for the fractionation of mixtures of biosynthetic porphyrins.