Abstract

Weak mechanical properties and poor protein adsorption capacity of sodium alginate (SA) limit its use in tissue engineering. In this study, glucosamine-grafted nanoplate-like hydroxyapatite (gHAp)–SA nanocomposite scaffolds were fabricated via solution mixture and freeze-drying method. Scanning electron microscopy, X-ray diffraction, Fourier transform infrared, and thermogravimetric analysis were used to characterize the gHAp/SA nanocomposites. The porosity, mechanical properties, and preliminary cell behaviour of the gHAp/SA nanocomposites were examined and compared with neat SA. The gHAp/SA nanocomposites show improved mechanical properties and superior cell viability to neat SA. Furthermore, both the mechanical and biological behaviours of the gHAp/SA nanocomposites are related to the content of gHAp. It has been demonstrated that the highly porous and mechanically robust gHAp/SA nanocomposite scaffolds hold promise in tissue engineering applications.

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