Population Genetics Theory: Another View

Abstract

In this reply to Kempthorne's critique of current population genetics theory (this symposium), I describe the differences in viewpoint and in choice of evidence which lead me to a more favorable conclusion. Kempthorne's attacks on the general selection model and on Fisher's Fundamental Theorem of Natural Selection have considerable justification; in both cases, however, qualification is preferable to demolition. Furthermore, recent advances in selection theory really meet Kempthorne's well-founded objections. Finally, the most substantial point in Kempthorne's critique is not that current population genetics theory is inoperable, but that it is practically impossible to apply to life-history problems. Computers, properly programmed, may provide a valuable way around this impasse. In addition, the necessity and the difficulty of manipulating one variable at a time have been with science for a long and exasperating time.