Abstract
BackgroundThough genetic and environmental determinants of systemic haemodynamic have been reported, surprisingly little is known about their influences on cerebral haemodynamics. We assessed the potential geographical effect on cerebral haemodynamics by comparing the individual differences in cerebral blood flow velocity (CBFv), vasomotor tone (critical closing pressure- CrCP), vascular bed resistance (resistance-area product- RAP) and cerebral autoregulation (CA) mechanism on healthy subjects and acute ischaemic stroke (AIS) patients from two countries.MethodsParticipants were pooled from databases in Leicester, United Kingdom (LEI) and São Paulo, Brazil (SP) research centres. Stroke patients admitted within 48 h of ischaemic stroke onset, as well as age- and sex-matched controls were enrolled. Beat-to-beat blood pressure (BP) and bilateral mean CBFv were recorded during 5 min baseline. CrCP and RAP were calculated. CA was quantified using transfer function analysis (TFA) of spontaneous oscillations in arterial BP and mean CBFv, and the derived autoregulatory index (ARI).ResultsA total of 100 participants (50 LEI and 50 SP) were recruited. No geographical differences were found. Both LEI and SP AIS participants showed lower values of CA compared to controls. Moreover, the affected hemisphere presented lower resting CBFv and higher RAP compared to the unaffected hemisphere in both populations.ConclusionsImpairments of cerebral haemodynamics, demonstrated by several key parameters, was observed following AIS compared to controls irrespective of geographical region. These initial results should encourage further research on cerebral haemodynamic research with larger cohorts combining different populations.
Highlights
Though genetic and environmental determinants of systemic haemodynamic have been reported, surprisingly little is known about their influences on cerebral haemodynamics
With the aim of pooling individual subjects data from different regions in an on-going international collaborative research study of cerebral haemodynamic changes following acute ischaemic stroke (AIS), we investigated systemic and cerebral haemodynamic parameters in healthy older and AIS populations derived from two different regional research centre databases in the United Kingdom and Brazil
A total of 100 participants were recruited from both centres, corresponding to 25 AIS patients and 25 ageand sex-matched control subjects from each centre
Summary
Though genetic and environmental determinants of systemic haemodynamic have been reported, surprisingly little is known about their influences on cerebral haemodynamics. With the aim of pooling individual subjects data from different regions in an on-going international collaborative research study of cerebral haemodynamic changes following acute ischaemic stroke (AIS), we investigated systemic and cerebral haemodynamic parameters in healthy older and AIS populations derived from two different regional research centre databases in the United Kingdom and Brazil. Data from these two regions were chosen in order to ensure the homogeneity of the measurement settings and reduce the interference of other confounding factors (e.g. transcranial Doppler inter-operator reliability), as only one researcher (AS) collected and analysed the data
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