Pooled-analysis of the association between TIM-1 5383_5397 insertion/deletion polymorphism and asthma susceptibility.

Abstract

The T cell immunoglobulin (Ig) domain and mucin domain 1 (TIM-1) gene play an important role in pathogenesis of asthma. We investigate the association between the TIM-1 5383_5397 insertion/deletion polymorphism (rs45623443) and the risk of asthma in an asthma case-control study, and added these data to a literature-based meta-analysis. The TIM-1 5383_5397 insertion/deletion polymorphism genotype was analyzed in 156 asthma patients and 162 healthy subjects from Han Chinese population. We combined our data with that from previously published studies and performed a meta-analysis to evaluate the effect of the gene. Through regression model, we found no significant association for TIM-1 5383_5397 insertion/deletion polymorphism in our cohort. Meta-analysis, comprising a total of 1,577 asthma cases and 1,781 controls, revealed that no significant association between and asthma susceptibility was observed (OR = 0.99, 95 % CI = 0.83-1.20 for Ins vs. Del; OR = 1.01, 95 % CI = 0.74-1.37 for Ins/Ins vs. Ins/Del + Del/Del; OR = 0.96, 95 % CI = 0.78-1.18 for Ins/Ins + Ins/Del vs. Del/Del). The present meta-analysis suggested that TIM-1 5383_5397 insertion/deletion polymorphism may not substantially contribute to asthma susceptibility. However, gene-gene and gene-environment interaction effects and other considerations involving this polymorphism may exit.