Abstract
Drug delivery research today is an advanced and important area in pharmaceutical research and application of nanotechnology includes enhancement of the solubility and permeability of the drugs so as to improve their bioavailability including delivery to the targeted site. Hydroxyapatite (HAP) based bioceramic nanoparticles composed of biodegradable polymers have been used in the present work to develop an amoxicillin based delivery systems. The synthesized n-HAP powders were estimated for the Ca/p ratio. This ratio indicates the presence of HAP as a single phase. The nano structure, morphology and presence of vibrational groups are con- firmed using instrumental analysis. The SEM images show the spherical shaped particles of nano hydroxyapatite are confirmed. The loading and unloading characteristics of the drug were recorded spectro photometrically.
Highlights
Various technologies have been explored for different routes of administration such as oral, parenteral, nasal, dermal, vaginal, etc
The synthesized nano hydroxyapatite (n-HAP) powders were estimated for the Ca/p ratio
It has been reported that the ultimate therapeutic and toxic effects produced by a drug, when administered as a solid dosage form and the resultant benefit or risk to a patient, are dependent on the sum of several interacting variables associated with the pharmacological properties of the drug, physiological and pathological factors associated with the patient and the physicochemical properties of the dosage form [1, 2]
Summary
Various technologies have been explored for different routes of administration such as oral, parenteral, nasal, dermal, vaginal, etc. Several products are available in the market based on these technologies and a large number of products are in clinical trials but they are yet to reach the patients In this context, nanotechnology has been shown to provide superior drug delivery systems for a better management and treatment of cancer and other diseases like AIDS, tuberculosis and malaria. For the treatment of human diseases, nasal and pulmonary routes of drug delivery are gaining increasing importance These routes provide promising alternatives to parenteral drug delivery for peptide and protein therapeutics. For this purpose, several drug delivery systems have been formulated and are being investigated for nasal and pulmonary delivery. In the present work nano hydroxyapatite (n-HAP) was synthesized and mixed with electrospun PVA and loaded with amoxillin drug and profile its release
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