Abstract
The antitumor effect of a polymer of aspartic acid, polysuccinimide, against murine solid-tumor models, such as Lewis lung carcinoma, AKATOL adenocarcinoma, and Ca-755 adenocarcinoma was found. The tumor growth inhibition was 60–80% compared to the control. The antimetastatic activity of polysuccinimide was found; in the Lewis lung carcinoma model it manifests itself in inhibition of lung metastases by 60% compared to the control. It was shown that polysuccinimide does not shift the pH values of tumors (P-388 lympholytic leukemia, AKATOL adenocarcinoma) into the region of acidic values. The experimental study indicates the advisability of further profound preclinical trials of the antitumor properties and mechanism of action of polysuccinimide.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
