Abstract
Wound management remains a worldwide challenge. It is undeniable that patients with problems such as difficulties in wound healing, metabolic disorder of the wound microenvironment and even severely infected wounds etc. always suffer great pain that affected their quality of lives. The selection of appropriate wound dressings is vital for the healing process. With the advances of technology, hydrogels dressings have been showing great potentials for the treatment of both acute wounds (e.g., burn injuries, hemorrhage, rupturing of internal organs/aorta) and chronic wounds such as diabetic foot and pressure ulcer. Particularly, in the past decade, polysaccharide-based hydrogels which are made up with abundant and reproducible natural materials that are biocompatible and biodegradable present unique features and huge flexibilities for modifications as wound dressings and are widely applicable in clinical practices. They share not only common characteristics of hydrogels such as excellent tissue adhesion, swelling, water absorption, etc., but also other properties (e.g., anti-inflammatory, bactericidal and immune regulation), to accelerate wound re-epithelialization, mimic skin structure and induce skin regeneration. Herein, in this review, we highlighted the importance of tailoring the physicochemical performance and biological functions of polysaccharide-based hydrogel wound dressings. We also summarized and discussed their clinical states of, aiming to provide valuable hints and references for the future development of more intelligent and multifunctional wound dressings of polysaccharide hydrogels.
Highlights
Wound is the damage of tissues and/or organs accompanied by the destruction of the integrity of the skin or mucous membrane (Gupta et al, 2019), which plays an extremely important role in preventing water loss and blocking the invasion of harmful substances and pathogenic microorganisms as a significant interface between the body and its surroundings (Zhou et al, 2021)
The distinctive characteristics of polysaccharide-based hydrogels such as high-water retention capacity, biocompatibility, biodegradability and tunable functionality make them competitive candidates in the application of wound dressing
In this review we discussed the influences of different gelling methods, i.e., chemical, or physical crosslinking on the mechanical, rheological, modeling time and swelling properties of the dressings that give the fundamental indications for designing appropriate wound healing materials
Summary
Wound is the damage of tissues and/or organs accompanied by the destruction of the integrity of the skin or mucous membrane (Gupta et al, 2019), which plays an extremely important role in preventing water loss and blocking the invasion of harmful substances and pathogenic microorganisms as a significant interface between the body and its surroundings (Zhou et al, 2021). 2020) (Fan et al, 2021), providing a physical barrier against secondary infection, and a compatible physiological environment Among all these advanced dressings, hydrogel becomes a rising star in rapid wound healing (Jacob et al, 2021), by providing a biocompatible, moisture, and antibacterial interface between the dressing and the wound (Zhang et al, 2019). We reviewed and analyzed the current states of polysaccharide-based hydrogel wound dressings that have been approved by FDA or in clinical trials. We hope this short review can provide some valuable hints and references for the future development of more intelligent and multifunctional polysaccharide hydrogel wound dressings
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