Abstract
AbstractPolyphosphazene polyacids are potent immunostimulating compounds. Formulation of these water‐soluble macromolecules into a microparticulate form can extend their utility in vaccine delivery applications. A simple method for the preparation of microspheres and nanospheres using polyphosphazene polyacids is reported. The key element of the process is ionic complexation of polyphosphazenes in aqueous solutions with physiologically occurring amines, such as spermine. A phase diagram of poly[di(carboxylatophenoxy)phosphazene] (PCPP)–spermine–water system is established, which shows an extensive area of microsphere formation. Microsphere size distribution is studied as a function of reaction conditions and concentrations of reactants. This method can be applied to polyphosphazene polyacids containing carboxylic acid and sulfonic acid functionalities and can be used for protein encapsulation. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 101: 414–419, 2006
Published Version
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