Abstract
ABSTRACTThe present study was designed to explore and validate the antifilarial activity of Murraya koenigii leaf extracts against Brugia malayi parasite. Anti-microfilarial activity of M. koenigii leaves extracted in methanol and ethanol (along with polyphenols depleted fractions) was determined. Ethanolic extract showed higher polyphenols content and anti-microfilarial activity compared to methanolic extract. Polyphenols depletion reduced such activity of ethanolic but not of methanolic extract. Ethanolic extract had lower alkaloids than methanolic extract. Ethanolic extract of M. koenigii leaves caused oxidative stress with concomitant apoptosis along with mitochondrial damage.Abbreviations: DEC: Diethyl carbamazine; DNPH: 2, 4 dinitro phenyl hydrazine reagent; DTNB: 5,5-dithio-bis-(2-nitrobenzoic acid); EB/AO: Ethidium bromide/Acridine orange; MDA: Mass Drug Administration; Mf: Microfilariae; PBS: Phosphate buffered saline; TCA: Trichloroacetic acid; WHO: World Health Organization
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