Abstract
Various epidemiological studies have shown an inverse association between the consumption of polyphenols or polyphenol-rich foods and the risk of cardiovascular diseases. The purpose of the study was to emphasize the effects of the association between the renin inhibitor and the polyphenolic extract on biochemical parameters and systolic and diastolic blood pressure. The polyphenols are extracted from isolated and purified vegetable material represented by the mature fruit of the Aronia melanocarpa. The experiment was performed on the arterial hypertension model. In the arterial hypertensive model the cardioprotective effects of the polyphenolic extract from Aronia melanocarpa are represented by the antioxidant, hypocolesterolemiant intervention. Polyphenolic extract from Aronia melanocarpa reduce systolic and diastolic arterial tension values in rats with drug-induced hypertension, a phenomenon more pronounced when polyphenols are associated with Aliskiren (renin inhibitor). The combination between the Aliskiren and polyphenolic extract produce superior hypolipidemic and antioxidant effects than in the case of separate administration within experimental arterial hypertension induced in the murine model.
Highlights
Polyphenols and other food phenolics are the subject of increasing scientific interest because of their possible beneficial effects on human health
The purpose of the study was to emphasize the effects of the association between the renin inhibitor and the polyphenolic extract on biochemical parameters and systolic and diastolic blood pressure
The combination between the Aliskiren and polyphenolic extract produce superior hypolipidemic and antioxidant effects than in the case of separate administration within experimental arterial hypertension induced in the murine model
Summary
Polyphenols and other food phenolics are the subject of increasing scientific interest because of their possible beneficial effects on human health. The fruit of the Aronia melanocarpa, a shrub of the rosaceous family, has a dark purple peel and contains high levels of flavonoids and phenolic acids. Main flavonoid subgroups in chokeberry are proanthocyanins, anthocyanins, flavornols and catechins [1]. More evidence for a protective role of polyphenols against cardiovascular diseases arose from a number of clinical trials [2], experiments on animal models and mechanistic studies [3]. Various epidemiological studies have shown an inverse association between the consumption of polyphenols or polyphenol-rich foods and the risk of cardiovascular diseases [4]. Since polyphenols are redox active compounds they may cause increased radical formation if they uncouple electron pathways in the body or if they chelate transition metals in such a way that they become more reactive like in the experimental Fenton oxidation systems [5]
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